Leaders of the snake-handling Signs Following Church in the hills of Appalachia are threatened by the snakes they handle to prove their Godliness and by the law enforcement and child welfare agencies of the surrounding community. They live side-by-side with the Blue People, a society of outcasts whose skin is marked by a blue skin tone. Into the mix comes Jay, a shy, possibly autistic, journalist intent on uncovering the secret world of these hidden cultures.